Plains Indians were living and hunting on Nose Hill for hundreds of years. Bands such as the Blackfoot, Sarcee and Stoney have used the Hill. Native settlements were temporary and seasonal as the people followed herds of buffalo around the prairie. Nose Hill would have provided a great vantage point for spotting herds of buffalo. Teepee rings are still evident in the park; unfortunately, many artifacts have probably been destroyed.
The first Europeans settled in the region in the 1700s. There was no significant development of the Hill until the 1800s. It has served as grazing land for cattle and horses and non-native vegetation has been introduced. . The plateau of Nose Hill has been used for agriculture. In recent years a gravel pit was located on the Hill
In 1973, the City of Calgary created Nose Hill Park, after a lengthy debate over what form it should take and what role it would play in the city's development. There are large areas of the Park which are still in a natural state. At 1093 hectares, Nose Hill is Canada's largest urban natural environment park and a precious example of a prairie landscape.